About

The Centre for Preclinical Drug Development (CPDD)

Transforming Today’s Discoveries into Tomorrow’s Therapeutics

The Centre for Preclinical Drug Development (CPDD) bridges the gap between academic discovery and clinical readiness, enabling investigators to advance from early stage drug discovery to preclinical development.

Our innovative and strategic approaches to critical preclinical studies support faster and more efficient decision-making, helping promising innovations progress toward clinical development.

Through our unique consultative approach to technology translation, CPDD leverages our platforms and expertise to help academic groups and startups maximize the potential of their discoveries.

Partners

Expertise & Services

  • In Vitro Biology and Assays

    • Cell-based target characterization

    • Mechanism-of-action evaluation

    • Biological screening assays

    • Biomarker identification


    Hit Identification and Lead Optimization

    • Hit-to-lead strategies

    • Lead optimization support

    • Medicinal chemistry collaboration

    • Computational chemistry support

  • ADME Studies

    • Microsomal stability

    • Plasma protein binding

    • Permeability assays

    • Solubility assessment

    • Metabolite profiling


    Pharmacokinetics (PK)

    • Rodent PK studies

    • Biodistribution studies

    • PK/PD relationships

    • Dose optimization

    • Exposure assessment


    Bioanalysis & Instrumental Analysis

    • LC-MS/MS method optimization

    • Quantitative bioanalysis

    • Small molecule analysis

  • Formulation Sciences

    • High Throughput formulation screening

    • AI-assisted drug delivery optimization

    • Liquid and solid dosages

    • Small molecule / salt screening

    • Nanoformulations

    • Physiochemical characterization

    • Release/Permeation profiling

    • Stability assessment

  • In Vivo Pharmacology

    • Efficacy / Disease model consultation
      and development

    • PK/PD integration

    • Dose response studies


    Early Toxicology Assessment

    • In vitro safety assessment consultation

    • Rodent dose tolerability studies

    • Preliminary in vivo safety assessment

    • Safety pharmacology support

Facilities & Infrastructure

  • State-of-the-art LC-MS/MS instrumentation

  • Bioanalytical platforms

  • Cell culture and assay facilities

  • Rodent pharmacology infrastructure

  • Formulation capabilities

  • Computational resources

Project Inquiry

Partner with CPDD through a collaborative, end-to-end process that moves from confidential consultation and expert project assessment to tailored study design, integrated preclinical research, and strategic decision-making support.

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